Effects of rhBMP-2 on some Biomarkers of Epithelial to Mesenchymal transition Process in the Gingival Epithelium


Abstract in English

Epithelial to mesenchymal transition (EMT) process represents an essential stage for tissue healing، it is also considered as a preface for tumour proliferation and invasion. The current study aimed to investigate the effects of rhBMP-2 protein on two essential biomarkers for this process : β-catenin and E-cadherin.

References used

Zhang, Y.G., et al., [Construction and bio-activity of the chimeric protein of BMP2-EGFP]. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2005. 30(1): p. 16-20
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McCormack, N., E.L. Molloy, and S. O'Dea, Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium. Respir Res, 2013. 14: p. 36

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