The aim of this experiment was to study the protective and therapeutic effects of Ecballium elaterium juice against experimental infection with Eimeria stiedae in rabbits. thirty- two rabbits Divided into four groups (eight rabbits in each group) : healthy control group; challenged –Ecballium elaterium –protected group, which received a daily dose of (45)μl\kg body weight Ecballium elaterium juice intra-peritoneal for five days before challenged with E. stiedae; challenged –Ecballium elaterium – treated group which received a daily dose of (45)μl\kg body weight Ecballium elaterium juice intra-peritoneal for five days after challenged with of E .stiedae and infected group. The challenge dose was 40000 sporulated E. stiedae oocyst per rabbit.