Evaluting Significance of Survivin as a biomarker in Syrian Patients with Bladder Cancer

Bladder cancer is the most common malignancy of the urinary tract, and has the fastest rate of recurrence which gives it high prevalence of tumors all over the world. Early diagnosis is very important for treatment efficacy, prevent tumor progression and prolong survival period, so many urinary markers have been studied but early diagnosis of carcinoma of bladder remains a challenge. Survivin is a member of the inhibitor of apoptosis protein family (IAPs), whose irregular expression is associated with tumor cell proliferation, progression, angiogenesis, therapeutic resistance, and poor prognosis.