A study was conducted to investigate the protective and therapeutic effects of Ecballium elaterium juice against experimental infection with Eimeria stiedae in rabbits. Thirty- two rabbits were divided into four groups (eight rabbits in each group) : healthy control group (HC); challenged – Ecballium elaterium –protected group (CEEP) which received a daily dose of (45) μl\kg body weight Ecballium elaterium juice intra-peritoneal for five days before challenged with E. stiedae ; challenged – Ecballium elaterium –treated group (CEET) which received a daily dose of (45)μl\kg body weight Ecballium elaterium juice intra-peritoneal for five days after challenged with of E .stiedae and infected group (IC).The challenge dose was 40000 sporulated E. stiedae oocyst per rabbits.