The effect of Rosuvastatin in the treatment of Rheumatoid Arthritis in rats


Abstract in English

The study has been done with Wister Rats have disease by 0.1 ml Complete Freund Adjuvent in right foot. At day 14 we gave Rosuvastatin (5- 20) mg/ kg PO and Dexamethazone 0.05 mg/kg IM until the day 28. At day 28 the joints have been studied hystologically.

References used

AARAVAK T, NATVIG JB. 2001. Cell-cell interactions in synovitis: antigen presenting cells and T cell interaction in rheumatoid arthritis (Review). Arthritis Res P:13-17
BARTOK B, FIRESTEIN GS 2010. Fibroblast-like synoviocytes: key effector cell in rheumatoid arthritis (Review). Immunol Rev VOL233, 233-255
BENOIST C, MATHIS D 2000. A revival of the B cell paradigm for rheumatoid arthritis pathogenesis? (Review). Arthritis Res VOL 2, 90-94

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