The aim of this experiment to study some of the blood parameters associated with hepatic coccidiosis induced by Eimeria stiedae in rabbits, and compare it with the blood changes when infected rabbits treating with the toltrazuril compound. 21 rabbit-old (4-8 weeks) were Used for this experiment of both sexes and were divided into three groups (seven rabbits in each group): Group of natural witness, and a Group of patient witness, where the infection caused by challenge dose of about forty thousand mature oocyst for each rabbit by mouth, and a treatment group that has been given the same previous challenge dose.