This study aimed to assessing the relationship between locus of control and depression among breast cancer patients. The study was carried out in the chemical and radiational treatment center in Tishreen University Hospital – Latakia, Data collected from15/12/2015 to 15/2/2016.The sample comprised of 100 breast cancer patients. Three tools was been used, the first tool (Demographic and Clinical Data Sheet) was been filling by the researcher, then all patients which participated in the study was asked to answer on the second tool (Rotter's Locus of control Scale) and the third tool (Beck Inventory Scale II). This study found that there was significant statistical relation between locus of controltype and depression degree among breast cancer patients, more than half of breast cancer patients was had depression, and was had external locus of control. So it is recommended study theeffect of training program to modify locus of control type on the incidence average of depression among breast cancer patients.