Nursing is considered to be one of the most stressful professions among the human services professions, it need compassion and involvement beyond physical care giving. Nurses have tremendous responsibilities and deal with enormous challenges, Burnout is one of these challenges, it is characterized by decreasing energy, power and resources in the presence of excessive demands. It is one of the factors which influence the efficiency and productivity of the workers and staff in every field. Aim: This descriptive study was aimed to assess burnout among 135 nurses, were randomly chosen, working in various section of Al-Assad university hospital. The data were collected by using a translated version of the Maslach Burnout Inventory-Human Services Survey. Results: Showed high levels of burnout among nurses as general Nurses working in Emergency Room, Intensive Care, Operation Room with Baccholrius degree had high level of Emotional Exhaustio (EE). Nurses young people experienced high level of Depronalization (D). Nurses working in night shift showed low level of Personal Accomplishment (PA(.No statistical significance was found between burnout and gende, marital status, work experience. Conclusions: this problem must be studied more deeply and related factors should be recognized in order to reduce burn out among nurses. Many affected aspects of nurse's job should be noticed and appropriate intervention should be conducted.