This study aimed to analyze the Internal determinants of Commercial bank profitability listed in Damascus Security exchange during the current crisis in Syria, To achieve that, the researcher collected data on all the listed commercial banks ,which their number of eleven banks and for the period 2011 – 2015. Where the expression of profitability, which represents the dependent variable in the study by rate of return on assets. While the determinants profitability included , which represents independent variables , all of the ( Bank age , Bank size, capital ratio, direct credit facilities index, credit quality, management efficiency ,Non interest income , cost efficiency, Evaluation Differences in Exchange unearned , rate of Deposits at Banks and rate of Investment in securities ).