The adreno-cortical hormones ,are considered one of the most important parts of the nonspecific reaction of the organism to different stress effects including the stress induced analgesia . This paper is interested in the study of the effect of repeated cold stress(swimming in cold water ١٧ c for ten minutes) and the emotional stress (immobilization for ten minutes) for the average of six times daily for six days,(on the test of tail flick latency) in normal and adrenalectomized rats . The aim is to know the analgesic system and their probable relation wth the adreno-cortical hormones .