Investigation The Expression of Chemokine Receptor CXCR4 in Head and Neck Squamous Cell Carcinoma-metastiatic lymph Nodes and Compare It with its Primary Tumor (clinical immunohistochemistry study)
published by Aِl-Baath University
in 2017
in Dentistry
and research's language is
العربية
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Abstract in English
this study Aimes to Investigate CXCR4 expression in primary head
and neck squamous cell carcinomas tumors in all clinical stages and
histological grades, then compare it with control normal oral
epithelial tissues.
Compare metastatic lymph nodes CXCR4 expression with their
primary HNSCC tumors at high stages which associated with
metastatic lymph nodes.
References used
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Janowska-Wieczorek A, Marquez LA, Dobrowsky A, Ratajczak MZ, Cabuhat ML. Differential MMP and TIMP production by human marrow and peripheral blood CD34+ cells in response to chemokines. Experimental hematology. 2000;28(11):1274-85
Ganju RK, Brubaker SA, Meyer J, Dutt P, Yang Y, Qin S, et al. The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. Journal of Biological Chemistry. 1998;273(36):23169-75