Hepcidin-25 is a peptide hormone plays an important role in regulating the systematic iron homeostasis. This paper was conducted to study the correlations of Hepcidin with some iron status markers and red cell indices among patients with iron deficiency anemia (IDA) and healthy controls in Damascus. Our study comprised 20 IDA patients (Hb≤11 g/dl for men and women,Tsat≤20% and ferritin <30 ng/dl) and 10 healthy non IDA controls. Complete hemogram was performed, iron status markers (serum iron, total iron binding capacity and ferritin) were measured and transferrin saturation was calculated .