The stock market conditions are a mirror reflecting the general economic situation in the country ,and the stability of these markets measure of the general economic policy of the country of success ,and then be trying to understand the fluctuations in stock prices and their relationship to economic ,financial and monetary factors and financial crises. The research examines the effect of inflation on the returns of index in Damascus Stock Exchange (DSE),the monthly data for the rate of inflation for the Damascus market indices has been collected during the period (2010-2013). The researcher concluded that there is a weak positive relationship but insignificant for inflation rate on the return of market index in( DSE) during the study period.