This study aimed to know the Psychological Loneliness and the meaning of life in a sample of women with infertility in Lattakia in the Syrian Arab Republic and the known differences between respondents depending on the variables of the study. Residence (rural, city), ( Less than 45 years,45 years and over), work (working, non-working), and the study descriptive analytical method has been adopted, and has taken a researcher from the questionnaire President to take the views of members of the tool The study sample consisted the Psychological Loneliness scale questionnaire was applied to a sample consisting of 74 women were selected randomly.