Sweeteners are used as alternatives of Sugar because of their slow absorption and incomplete metabolism in human body, which are positively destinies in setting free small amount of calorie. This research presents the influence of ultrasonic on the sorbitol synthesis, starting from Glucose by implementing hydrogenation using Lithium Aluminum Hydride. The result we have reached by using the ultrasonic as compared with mechanical mixing or other method have lead us to two conclusions: The first was that we have obtained almost the same quantity of the sorbitol. The second was that by using ultrasonic, micelles of colloid Aluminum hydroxide were accumulated. This accumulation resulted in an easy separation by purification, which eventually lead to a super pure sorbitol solution. We hope that these results will be useful for the Crystallography science.