Malignant Pleural Effusion is a common complication of advenced malignancies، Particularly lung and breast cancer. Many patients experience considerable dyspnea shortness of breath، dry cough and chest pain، wich decisively reduces their capacity for physical activity and their quality of life. Between 1995 – 1998. 39 cases with malignant pleural effusion were treated. Pleurectomy was performed in 4 cases .The lung was trapped in 5 cases.Pleurodesis with talc slurry for 25 cases، with Tetracyclin for 4 cases and with Bleomycin for one case were performed. 73% - of these cases had positive results (decrease the dyspnea، no effusion) during 1st month .and 66،6% had positive results too during 3 months. So ،Pleurodesis is an effective and ، simple method of manegement of malignant Pleural effusion It has also low cost and low complications.