In this work ,we try to predict the disadvantages will be caused by active suspension system on indirect tire pressure monitoring systems (TPMS) which rely on analysis either rotational speed signals of wheels or vehicle body vibration signals. Active suspension systems that aim to increase passengers comfort apply some additional vertical loads on vehicle's wheels which may cause difference in its rotational speed due to the resulting load difference. also it may change the vibration level of the vehicle during driving so the usage of vibration signals for monitoring tire pressure could be difficult or impossible . in both cases the performance of TPMS may be changed. This study showed that TPMS which rely on rotational speed signals will still able to work and the effects of active suspension system will confine on the quality of the resulting warnings while the TPMS which depend on vibration analysis will conk if the analyzed vibration data was the vertical acceleration signals of wheels .