Structure-Based Rational Design of Novel Analogues of Nimesulide
published by Aِl-Baath University
in 2017
in
and research's language is
العربية
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Abstract in English
Nowadays, the usage of NSAIDs has been increased dramatically
for relieving pain and the treatment of divers inflammatory
conditions, therefore, it is necessary to develop this class of drug
by increasing their activity and decreasing their side effects. Their
most common side effect is the gastrointestinal disorders,
especially, gastric bleeding resulting from the inhibition of
prostaglandins synthesis.
References used
Mahajan, A. & Sharma, R, 2005 COX-2 selective nonsteroidal antiinflammatory drugs: current status. J Assoc Physicians India, 53, 4-200
Chan, F.K. et al. 2002 Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. New England Journal of Medicine 347, 2104-2110
Rainsford, K.D. & Members of the Consensus Report Group on, 2006 N. Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med Res Opin 22, 1161-70