This study aimed to compare the susceptibility of five wheat varieties Eratom, Al-Iz, Rabea, ACSAD and Om-Rabei to infestation by Khapra beetle by estimation of population density of insect phases, population reproduction rate and the loss in germination percentage at two levels of infestation 2 and 4 pairs/ 100 gr. grains and four storage periods 3, 6, 9 and 12 months under natural conditions. Results showed significant differences between varieties. Eratom was the most susceptible variety and the population density, population reproduction rate and loss in germination percentage were 2868.08 individual, 77.61 individual/month and 65.82%, while ACSAD was the least susceptible one and the values were 1004.91 individual, 23.88 individual/month and 47.49% respectively. Also infestation level and storage period had a significant effect on the population density, population reproduction rate and loss in germination percentage.