Damascus is located at the southern part of Syria not far from the Dead sea fault system, in particular from one of its branches the Sergayah fault. The latter in particular is a quite active fault system and the main seismic source for both destructive historical events felt and instrumental seismicity recorded in Damascus. To model seismic ground motion in Damascus plain and to estimate its amplifications we use a 2-D hybrid method coupling modal summation with finite differences. This techniques allows to compute ground motion in laterally heterogeneous an elastic media. Synthetic seismograms with a cutoff frequency of 5 Hz are created along one 2-D profile passing through the city of Damascus for possible seismic source with assumed magnitudes around 6.5 located on the Sergayah fault. The average regional structural model and the laterally heterogeneous parts of the profiles have been derived from detailed geological and geotechnical data available for the investigated area. From the computations we can infer that the maximum ground motion amplification values in Damascus plain are generally found at frequencies around 1 Hz and 4 Hz. In addition for assessing liquefaction potential in Damascus plain tow methods have been used. first one evaluated roughly liquefaction potential based on topographical and geological information and the second one based on geotechnical data such as N- value, grain size and estimated peak ground acceleration to calculate a liquefaction resistance factor, FL. and liquefaction potential index, IL. We found that IL exceeds 15 which mean probable sever liquefaction.