Fatigue is one ofthemostimportant and common side effectamong cancer patient under chemotherapy. Objective:the study aimed is to study the effect back, hand and foot massage on fatigue levelto cancer patient under chemotherapy.Material and method:the study was conducted of (75) patients were adult male divided on five groups (back massage, hand massage, foot massage,[back, hand and foot massage] and control group) atchemotherapy unit, Tishreen University Hospital, and all of them are under chemotherapy. Data collected by the personal information form, the fatigue severity scale was used.Results:This study showed that back, hand and foot massage together was the most effective in reduce fatigue levels and recommended about importance of massage for patients under chemotherapy.