Objective: to study and evaluate the surgical operative process in the management of Benign Tumors and Leukoplakia in the Oral Cavity by using Laser CO2. Materials and methods: a total of 18 patients (10 males and 8 females) with mean age 50 years, and diagnosed with Benign tumorous Lesions or Leukoplakia on mucosa of the oral cavity, were treated by Vaporization by using CO2 Laser in Al-Assad university hospital. The postoperative complications were recorded within 7 days after the surgery, and the wounds was assigned until entire healing. Results: 8(44%) patients had week pain after 24 hour of surgery, and reduced to 2(11%) patients in the third day. Edema was seen by 8(44%) patients after 24 hour of surgery, and reduced to 1(6%) patient in the third day.5 (28%) patients showed disturbance within oral functions, and became 1(6%) patient in the third day. No complications were seen after 7 days of surgery. No infection or bleeding were recorded within following time.no statistically significant differences between Lesion kind and pain degree, and no relationship between Pain degree and Disturbance of the Lesions. Entire healing was satisfactory in all Wounds and no scar were seen . Conclusion: CO2 Laser is effective method in manage and minimize the complications during Healing process after the management of Benign Tumors and Leukoplakia in oral cavity.