This study was carried out in the department of anesthesia and reanimation at ALASSAD , TishreenUniversity Hospitals ,Lattakia,Syria,during the year 2014 - 2015,and included 60 patients of either sex (20 – 60 years of age ) under going elective laparoscopic cholecystectomy. Patients were divided into two groups: Patients of group G received oral gabapentin 600 mg 2 hours before inducation of anesthesia , while patients in group p did not receive any drug before the surgery. The goal of the study is studying The effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy Results : there were significantly hemodynamic stability in patients of group G as compared to group p. Conclusion : Gabapentin premedication provided perioperative hemodynamic stability during laparoscopic cholecystectomy.