Thirty-two patients with port-wine stain were included in this study. The 585 nm pulsed dye laser treatment with an air cooling device was repeated 4 times at 8 – week intervals with a setting of 0.5 ms pulse duration and an average energy fluence 5 - 6.5 J/ cm2, using 7 mm spot size. The results revealed improvement of port-wine stains after multiple treatments , and 69% of the patients achieved good or excellent clearance after the fourth treatment. Transient purpura and tolerable pain were noted immediately after each treatment (87.5%), crusting (25%), hypopigmentation (9%), hyperpigmentation (6%) were also mild and their occurrence didn’t increase by repeating treatment. The results of this study indicated that the 585 nm PDL is effective and well tolerated in the treatment of port wine stain.