The effect of lead exposure on rate of spontaneous abortion of workers at a battery factory was studied. The study comprised 25 male workers in a leadsmelter and controls of 24 male university employees without any known occupational exposure to toxic agent. The most interesting outcome of the present study has been the discovery of high incidence of spontaneous abortion in lead-exposed workers compared to that of controls. Comparative evaluation between smokers and non-smokers with respect to the incidence of spontaneous abortion does not exhibit any statistically significant variations in lead-exposed workers and controls as well. However, such findings are considered to be indicative of the possible existence of a genetic risk and sufficient for justifying further work on a wider scale of risk assessment and occupational hazard in Jordan.