Groundwater is an important source of drinking water. Therefore; groundwater contamination is a source of continuing concern. Groundwater contamination is unlike surface water contamination, because it is difficult to define and harder to be controlled and treated. It may also last for years or decades. Deveh Spring area is an agricultural area in Lattakia. It suffers from many environmental problems, so, it is very important to assess spring water vulnerability using DRASTIC and create water vulnerability assessment map by GIS. The map showed that the recharge water to Deveh Spring has a high and moderate vulnerability to contamination. The area of high vulnerable groundwater zone is (82Km2), which is about (48%) from the whole study area. The area of moderate vulnerable groundwater zone is (40Km2), which is about (23%) from the whole study area. Sufficient actions must be taken to protect water from contamination, through the integrated management of groundwater resources.