A Study of Some Factors Influencing Encapsulation Yield& Efficacy When Preparing Microcapsules By Complex Coacervation


Abstract in English

The Objective of this study was to prepare Paracetamol Microcapsules using Gelatin type A and Gum Arabic as a hydrophilic polymers. Microcapsules were prepared by complex Coacervation. Microencapsulation Yield (MEY) and microencapsulation efficacy (MEE) were investigated with respond to three variables including: Ratio of core to wall material (2:1, 4:1, 6:1), Stirring Speed (200, 300, 400) rpm and Drying method (Air at room temperature, Oven at 26ºC). The results showed that increasing core to wall material leads to increase in both MEE & MEY. The same effect was obtained when increasing stirring speed. Finally the change in a way drying leads to unnoticeable change in both MEE & MEY. Optimum MEE & MEY were obtained when using 6:1 core to wall material, 400 rpm in both two ways of drying.

References used

Agnihotri, N.; Mishra, R.;Goda, C.&Arora, M.Microencapsulation – A Novel Approach in Drug Delivery: A Review. Indo Global Journal of Pharmaceutical Sciences, Vol.2, NO.1, 2012, 1-20
Dubey, R.; Shami, T.C.&BhaskerRao, K..U. Microencapsulation Technology and Applications.Defence Science Journal, Vol.59, No.1, 2009, 82-95
Siow,L.F.&Ong, C.S. Effect of pH on Garlic Oil Encapsulation by Complex Coacervation. Journal of Food Process& Technology, Vol.4, NO1, 2013, 1-5

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