The experiment was carried out at the research stations of Salo in Deir- Azzor agricultural research center and Tel Sandal in Idlib agricultural research center. Land plots infected previously with sesame wilt disease, Macrophomina phaseolina (Tassi) Goid, and Fusarium oxysporum Schlecht were cultivated for two growing seasons (2007 and 2008) with medicinal species such as, Cumin (Cuminum-sativum), Black seed (Nigella sativa L.) and Fenugreek (Trigonella foeniculum L.) and another infected plot was left blank as a control plot. Zuri, a local sesame variety, was cultivated in all plots for two growing seasons (2008 and 2009). Results showed that the control plots had the highest percentage of infected sesame plants compared to the lowest percentage found in those plots that had been cultivatd previously with Black seed, Cumin, and Fenugreek. Plots cultivated previously with Black seed gave the highest sesame yield and followed by those plots of Cumin. The The average percentage of germination of sesame, as a phenological growth indicator, was increased in those plots planted before with Cumin and the average number of capsules per plant was increased at both locations by 36.75 capsules after Black seed in comparison with the control.