This research was conducted at Abu Jerash farm, Faculty of Agriculture, Damascus University during 2011/2012 season to assess the effect of different doses and concentrations of physical and chemical mutagens on some quantitative and qualitative traits in the second generation (M2) of two varieties of durum wheat. Results showed significant differences (p<0.05) between the varieties, treatments and the mutual interactions. Bowhoth 9 was superior in the average of total number of changes (16.59%) compared with Doma1 (13.29%). The total number of qualitative changes in the varieties studied was 14 types of change, alternated and varied in appearance with the different doses and concentrations of mutagens used. Bowhoth9 was superior in the average of grain`s number (238.84), grains weight (11.89g) and the one thousand grain`s weight (58.35g) in comparison with the parallel counterparts of averages 174.31, 7.06g, 54.38g, respectively in Doma1.