This study was achieved to identify some characteristics of clay minerals of soils in the southern of region (provinces of Daraa, Sweida). Several soils profiles were selected, forming a toposequence, including the western slope of Jabal Al Arab and part of Huran plateau which rise about 500-1200m a.s.L. and rainfall between 250-350mm. These soils usually are planted with rainfed crops and some trees. Three samples were collected from each profile at depth 0-25 cm, 25-50cm and 50-100cm in order to determine some physical and chemical of soli characteristics and x-ray and Differential Thermal Analysis (DTA) were applied to determine the mineralogical composition of clay minerals. Results indicated that the soils had an clayey texture (37.9 % in Tafas Dr2 to 67.5% in Tal al Haded SW2), rather high CEC (35-49.4) meq /100g soil, neutral pH in Sahwa blata SW1 soil (7.1) to slightly alkaline pH (8) in other soils, low content of organic matter (1)%. CaCO3 ranged of (3.16)% in Sahwa blata SW1 soil to (25.35)% in Tafas Dr2. Cacium was the dominant cation on the exchange complex (33.11mq/100g) in TafasDr2, and followed by magnesium (13.99 mq/100g) in Tal al Haded SW2. Mineralogical analsis by x-ray and DTA showed the presence of three main clay minerals, Smectites (montmurillonite), Kaolinite and Mica (probablly illite).