The main objective was to study the economic efficiency of Durum wheat in AL-Hassaka governorate during the growing season of 2010/2011 through a stratified random sample included 119 farmers distributed in 10% of the target villages. The results showed that Duma 1 variety had achieved the highest proportion in relation to the rate of adoptions and the highest adoption rate compared with other varieties cultivated with irrigated Durum wheat in ALHassaka governorate. Sham 3 variety had also the highest adoption rate (47.47%) and widely distributed compared with other varieties Durum wheat cultivated as a rain fed crop. The results also showed that the net return of irrigated Durum wheat was in AL-malkia and amounted to 1653.17 Syrian Liras/ Dunum while losing -261.50 Syrian Liras per Donum in AL-kamshli. Duma 1 variety reached the highest net return (2443.58 Syrian Liras per Donum) of irrigated Durum wheat. The net return of rain fed Durum wheat was observed in AL-Malkia and amounted to 792.92 Syrian Liras per Donum while losing -158.18 Syrian Liras per Donum in AL-kamshli. Sham 7 variety had the highest net return of rain fed Durum wheat and amounted to 1847.48 Syrian Liras per Donum.