The purpose of this study was to investigate the relation between dental anesthetic and pulse and blood pressure. A sample of 600 patients was taken randomly ( 322 males - 278 females). The research was done on patients by giving dental anesthetic with and without adrenaline . The results of the study indicated that: - The heart rate and blood pressure of the patients receiving an injection of xylocaine without adrenaline increased by average of 4% -5% respectively. - The heart rate and blood pressure of the patients receiving an injection of xylocain with adrenaline increased by average of 12%-15% respectively. - the heart rate and blood pressure were mesured after 15 minutes we found that there was not any change in the value from the previous result. - when the heart rate and blood pressurewere mesured after 30 minuts hour we found that: - The heart rate and blood pressure returned to the normal value in case an injection without adrenaline . -in case an injection with adrenaline the heart rate increase by 1 puls The blood pressure l increased by 1 cm.m.