Stability–indicating HPLC Assay Method of Aspartame


Abstract in English

The purpose of this work is to develop a sensitive, selective and validated stability–indicating HPLC assay for the analysis of aspartame tablets. Aspartame and its potential impurities or degradation products are analyzed on C18 Column using a mobile phase containing monobasic potassium phosphate buffer solution (pH = 3.5) and acetonitrile (85: 15).

References used

Coiffard,C; Coiffard,L-j-M and Roeck-Holtzhauer,YDE. Pharmazie 1998, 53: 251 – 253
The Merck index 12 th edition whitehouse Station. NJ 1996: 141 – 142
Peigne, F; Stojanovic, S; Couteau, C; Coiffard, LJM Sciences des aliments. 2000, 20: 523-525

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