The aim of this study is to determine the incidence of helicobacter pylori (HP) in patients with chronic gastroduodenitis and to compare the clinical presentations between patients with positive HP chronic gastroduodenitis and those with negative HP. Also, To compare the endoscopic findings between patients with HP positive gastroduodenitis and HP negative children. Gastroduodenoscopy was done for every child with abdominal pain admitted at the children hospital-Damascus University between 2002-2003. Mucosal biopsy was taken from every patient who had gastroduodenitis diagnosed by gastroduodenoscopy. The percentage of patients with gastroduodenitis having HP positive erosions was 48.38 %. Higher percentage of HP positive patient was more present in those with the erosion and sub-atrophy forms.