The study was conducted in the eastern region of Syria to know the extent of cultivation development of wheat and cotton production and the factors affecting these crops during 1996-2010. The results showed that the effect of time on the production and productivity of wheat was not changed statistically, while the cotton area was decreased significantly during the study period. The total production of wheat was also affected significantly and positively by cultivated area and planting costs per hectare, and negatively by purchase price, while the production of cotton was affected significantly and positively by costs and purchase prices. According to the geographical region, the results showed that the production in the eastern region was significantly affected by Al-Raqqa production for wheat and cotton crops and Al-Hassake production for wheat crop. However, wheat productivity at Deir Ezzor was significantly superior compared to Al-Raqqa and Al-Hassake. The study recommended expanding the cultivation of wheat and cotton and support and expand the role of agricultural extension.