The study area (1485 km2) is located in the eastern part of the Syrian Desert between the provinces of Deir al-Zour and Homs. Stretching from Kabbajeb to Heer Palace. Due to the similarity of topography, vegetation and land cover, 48 samples were collected one sample each 4 KM in order to predict the content of the soil of calcium carbonate through satellite images Land Sat ETM7. The spectral reflections of surface soil samples were recorded at laboratory using spectroradiometer (FeildSpecPro®). The results of this study showed that the presence of calcium carbonate at high rates in the soil increases the spectral reflectivity values, and that the spectral domain TM 1B was the best to predict the content of calcium carbonate in the soil.