Our results assured the presence of functional association between the pigment epithelium (P.E) and photoreceptors of eye retina of lacerta laevis. The continuous effect of He-Ne laser on eye produce dangerous structure changes (according to studies by transmission electron microscope) led to damage of parts and organelles of pigment epithelium and photoreceptors of eye retina. The displacement of the epithelium from the photoreceptors layer was the first dangerous results on vision (Retinal detachment). This detachment conduced to no protection of photoreceptors from high intense light (which usually maintained by melanin pigments spread in epithelium cells surrounding the outer segments [O.S] of photoreceptors) so that the outer segments of photoreceptor became under the influence of intense light of He-Ne laser which conduced to damage of cytoplasmic membrane of outer segment disks and damage of chemical structure of visual pigments (pigment necessary for discrimination of color in cones) so the photo sensible pole lost its function in transferring the sign of light necessary for vision. The lesion happened by the influence of He-Ne laser in the cones, associated by dangerous changes in the retardation of nucleus size and damage of chromatin material and the absence of organelles responsible for biological synthesis of cellular protein, and deconstruction of glycogen molecules (energy mols.). The most dangerous thing is the resulted damage of synaptic pedicle of cones (lost of connection between bipolar nerve cells and synaptic ribbons) so the neurotransmission pole lost its function in neurotransmission across the layer of neurosynapsis of retina. The damaged photoreceptor cells (cones) (which were almost dead) became disables to do their function in vision.