cytokines production is associated with diabetes mellitus and in its turn is associated with infiltration of the islets of Langerhans with autoreactive lymphocytes and specific destruction of the insulin-producing B cells. Our aim is therefore to investigate the effect potential role of the effect of the cytokine especially (interleukin-1B, interleukin-6, interleukin-8) and Creactive protein (C.R.P.) on the microvascular complications of diabetes (nephropathy).