Enterobacter sakazakii is considered an opportunistic pathogen that has been associated with severe lethal infections especially in neonates, elderly, and Immunocompromised adults. E. sakazakii is a Gram negative, facultative anaerobes rod-shaped bacterium. It belongs to the family Enterobacteriaceae and genus Enterobacter. Although we don’t know the natural habitat of this bacteria we find that it exists in high rate in herbs and spices which indicates that plant may be this natural habitat.