Seasonal changes effect on yield and quality of carrageenan from the Syrian marine alga Hypnea musciformis were studied during 1 year. The carrageenan yield varied from 31 to 46%. The maximum yield was recorded between April and September, while low carrageenant content was recorded in December. The gel strength of carrageenan was maximum in September (260 g/cm²) and minimum in March (90 g/cm²). The viscosity ranged from 22 to 44cP with a peak recorded in September. Seasonal variations were not observed in the gelling (42-50 C°) and melting (60-70 C°) temperatures of carrageenan. The results indicate that Hypnea musciformis can be considered a good sources for production of commercial carrageenan in future.