Expression of Human Epidermal and Transforming Growth Factor Receptors in Normal Bone Marrow Cells and Leukemic Cells (Myeloid Leukemia and Lymphatic Leukemia)
published by Damascus University
in 2006
in Medicine
and research's language is
العربية
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Abstract in English
The goal of this research is to study the expression of epidermal and
transforming growth factor receptor in normal human bone marrow (BM)
cell, and in leukemia ( myeloid and lymphatic leukemia ) which promoted
the research for the function of EGFR receptors in the development and
growth of BM cells and for malignancies expressing of the EGFR as
potential therapeutic targets in blood cell malignant diseases.
References used
Allen TD, Dexter TM, Simmons PJ: Marrow biology and stem cell, in Dexter TM, Garland JM, Testa NG (eds): Colony-stimulating factors. New York, NY, Dekker, 1990, p 1
Anklesaria P, Texido J, Laiho M, Pierce JH, Greenberger JS, Massague J: Cell-cell adhesion mediated by binding of membrane anchored transforming growth factor α to epidermal growth factor receptors promotes cell proliferation. Proc Natl Acad Sci USA. 1990; 87(9):3289-93