The empty sella syndrome (ESS) is an asymptomatic radiological syndrome, affecting 6% of post-menopausal women and can be seen in all ages. The results were similar with other studies in many respects, such as a wide age spectrum including children, and the occurrence of diabetes insipidus in 5.97%. The results of our study were discordant with other studies with respect to hyperprolactinemia which reached 58.2% in our study (in other studies did not exceed 33.7%). No concurrent cases of secretory pituitary adenomas were found (studies refer to an incidence of acromegaly and Cushing’s syndrome in 2.6% of ESS for each). We did not record CSF rhinorrhea nor were visual disturbances seen in our cohort. Patients received symptomatic treatment and none were referred to surgery.