This study was organized to find out the role and the efficacy of Misoprostol in treating postpartum hemorrhage unresponsive to traditional agents that contract the uterus . Place : Maternity hospital at Faculty of Medicine in Damascus university Time : from 2, January, 2004 to 2, January, 2005 . Number of patients : 18 patients who met the criteria in that period of time . Criteria of selection : any patient with post partum hemorrhage due to uterine atony that did not respond well to the administration of Oxytocin and Metergin . Misoprostol is an effective treatment of post partum hemorrhage due to uterine atony unresponsive to Oxytocin and Metergin. Our study confirms the results of international studies of effectiveness of the use of misoprostol in treating post partum hemorrhage due to uterine atony.