Osteoarthritis (OA) is a frequent cause of joint pain and is estimated to be the most common cause of disability in adults. The goals of management of patients with osteoarthritis (OA) are to control pain and swelling, minimize disability, improve the quality of life, and educate the patient about his or her role in the management team. The effects of intraarticular hyaluronans in OA have been the subject of several studies. Their aim has been to determine whether intraarticular supplementation of these macromolecules, which are deficient in degenerative cartilage, can lead to decreased symptoms of osteoarthritis.