Cutaneous Leishmaniasis (CL) is one of the most prevalent clinical forms of leishmaniasis , also it is endemic disease in Syria. And in spite of the great efforts to control the disease the annual incidence is still increased. Furthermore, tourism, migration, and prevalence of acquired immunodeficiency (AIDS) all these factors increase the spread of this disease to new areas around the world. Recently, studies suggest that cytokines gene polymorphisms can contribute to resistance or susceptibility to many diseases and one of these diseases is CL .