Khat chewing is a deep-rooted habit in Yemen. It has many negative impacts on different body systems. The spread of khat chewing among adult males in Yemeni society needs special attention. Cathinone and cathine are the most stimulants of khat ingredients. Other ingredients could have other implication such as gastrointestinal carcinogenic tannins. the aim of this study is to Investigate chronic khatchewing effects on oral mucosa and the role of concurrent smoking.