The efficacy of tetracycline in the treatment of the recurrency of pemphigus vulgaris occurring during the period of steroid reduction


Abstract in English

Pephigus vulgaris is a recurrent life threatening disease. Its basic treatment is systemic steroids, after treating the first attack of the disease by systemic steroids we start to reduce the dose of the steroids gradually. During this reduction the desease may flare up, this recurrence is routinely treated by increasing the dose of the steroids again to control the disease, this study was made to compare the benefits of tetracycline in controlling the recurrence of pemphigus vulgaris with the routinely used way which is elevating the dose of prednisolone.

References used

Chams-Davatchi C ,et al. Randomized controlled open-label trial of four treatment regimens for pemphigus vulgaris. J Am Acad Dermatol 2007 Oct;57( 4): 622-628
Gouveia C, Coutinho V, Filipe P, Cirne-de-Castro J. Morbidity and mortality from steroid therapy in pemphigus. J Am Acad Dermatol 2004 Mar: P96
Ioannides D, Chrysomallis F, Bystryn J. Ineffectiveness of Cyclosporine as an Adjuvant to Corticosteroids in the Treatment of Pemphigus. Arch Dermatol 2000;136:868-872

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