This study aims to find the best social and economic factors that affect the number of students in higher education using the descriptive analysis approach, and find the mathematical model that connects the principal components representing the social and economic factors and the number of students in higher education in Syria. The most important results that have reached were the principal components representing the social and economic factors, after doing the orthogonal rotation and was representing the first component (number of members the labor force that are gainfully) employed, the number of population per health doctor, number of members, the labor force that are self-employed, number of members the labor force that are unmarried, number of population per dentist, higher education budget, and number of nurses. And the four thcomponent (number of members the labor force that are married), both components affected positively on the number of students in higher education, the second component (economic activity rate of the human power, average number of people per pharmacist, number of members the labor force that are gainfully unemployed, the third component (number of members the labor force that are divorced and widowed) affected negatively on the number of students in higher education.