This research has done in aiming for the effect of extract of Nerium oleander plant in the level of blood sugar and total glucose , triple alglesiredat and total cholesterol on created albino mouse which has got diabetes. The results showed the following: - A Significant increase in the concentration on bothglucose, triple alglesiredat and cholesterol through a serum in the blood of created albino mouse which has got diabetes, while the weight decreases comparing to the control. - The injection of Aqueous extract led oleander leaves plant with dose of 200 mg / kg of mouse weight for a period of ten days to a significant decrease of concentration on glucose ,the rate of total cholesterol and triple alglesiredat, in addition to, the weight has returned to what it was before the injection.