For studying the effect of cadmium sulphate on some physiological components of blood in male white rabbits. we used (12) animals divided in to two groups (6 animals per group).the experimental one became aqueous cadmium sulphate (5 mg/kg) orally, while the control became water for 28 days (4 weeks). We reported significant decrease (p<0.01) in the count of red blood cells , Hematocrit values and Hemoglobin concentration.